Sleep apnea syndrome in Parkinson's disease. A case–control study in 49 patients
Identifieur interne : 001422 ( Main/Exploration ); précédent : 001421; suivant : 001423Sleep apnea syndrome in Parkinson's disease. A case–control study in 49 patients
Auteurs : Nico J. Diederich ; Michel Vaillant [Luxembourg (pays)] ; Mike Leischen [Luxembourg (pays)] ; Giovanna Mancuso [Luxembourg (pays)] ; Serge Golinval ; Romain Nati ; Marc SchlesserSource :
- Movement Disorders [ 0885-3185 ] ; 2005-11.
English descriptors
Abstract
In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG). We performed a case–control study with retrospective analysis of PSG data of 49 PD patients. After classifying the PD patients according to their apnea/hypopnea index (AHI), they were matched with 49 controls in terms of age, gender, and AHI. There were 21 PD patients (43%) who had sleep apnea syndrome (SAS), classified as mild (AHI, 5–15) in 10 patients, moderate (AHI, >15–30) in 4 patients, and severe (AHI, > 30) in 7 patients. PD patients had more deep sleep (P = 0.02) and more nocturnal awakenings (P < 0.001) than the controls. Their body mass index (BMI) was lower (P = 0.04), and they maintained a more favorable respiratory profile, with higher mean and minimal oxygen saturation values (P = 0.006 and 0.01, respectively). These differences were preserved when only considering PD patients with AHI > 15. PD patients had less obstructive sleep apneas (P = 0.035), independently from the factor AHI. Only the respiratory changes of 4 PD patients with BMI > 27 and AHI > 15 (8%) approximated those seen in the controls. At an early or middle stage of the disease, non‐obese PD patients frequently have AHI values suggesting SAS, however, without the oxygen desaturation profile of SAS. Longitudinal studies of patients with such “abortive” SAS are warranted to establish if this finding reflects benign nocturnal respiratory muscle dyskinesia or constitutes a precursor sign of dysautonomia in PD. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20624
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-11">2005-11</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1413">1413</biblScope><biblScope unit="page" to="1418">1418</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2E951428A01B4252E7CA3E1E8652C6D3B2AD821A</idno><idno type="DOI">10.1002/mds.20624</idno><idno type="ArticleID">MDS20624</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>excessive daytime sleepiness</term><term>polysomnography</term><term>sleep apnea syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG). We performed a case–control study with retrospective analysis of PSG data of 49 PD patients. After classifying the PD patients according to their apnea/hypopnea index (AHI), they were matched with 49 controls in terms of age, gender, and AHI. There were 21 PD patients (43%) who had sleep apnea syndrome (SAS), classified as mild (AHI, 5–15) in 10 patients, moderate (AHI, >15–30) in 4 patients, and severe (AHI, > 30) in 7 patients. PD patients had more deep sleep (P = 0.02) and more nocturnal awakenings (P < 0.001) than the controls. Their body mass index (BMI) was lower (P = 0.04), and they maintained a more favorable respiratory profile, with higher mean and minimal oxygen saturation values (P = 0.006 and 0.01, respectively). These differences were preserved when only considering PD patients with AHI > 15. PD patients had less obstructive sleep apneas (P = 0.035), independently from the factor AHI. Only the respiratory changes of 4 PD patients with BMI > 27 and AHI > 15 (8%) approximated those seen in the controls. At an early or middle stage of the disease, non‐obese PD patients frequently have AHI values suggesting SAS, however, without the oxygen desaturation profile of SAS. Longitudinal studies of patients with such “abortive” SAS are warranted to establish if this finding reflects benign nocturnal respiratory muscle dyskinesia or constitutes a precursor sign of dysautonomia in PD. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Luxembourg (pays)</li></country></list><tree><noCountry><name sortKey="Diederich, Nico J" sort="Diederich, Nico J" uniqKey="Diederich N" first="Nico J." last="Diederich">Nico J. 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